Expression of chemokines and their receptors in human and simian astrocytes: Evidence for a central role of TNFα and IFNγ in CXCR4 and CCR5 modulation
Identifieur interne : 00AF29 ( Main/Exploration ); précédent : 00AF28; suivant : 00AF30Expression of chemokines and their receptors in human and simian astrocytes: Evidence for a central role of TNFα and IFNγ in CXCR4 and CCR5 modulation
Auteurs : Juliana Croitoru-Lamoury [France, Australie] ; Gilles J. Guillemin [Australie] ; François D. Boussin [France] ; Barbara Mognetti [France] ; Laure I. Gigout [France] ; Arnaud Chéret [France] ; Bruno Vaslin [France] ; Roger Le Grand [France] ; Bruce J. Brew [Australie] ; Dominique Dormont [France]Source :
- Glia [ 0894-1491 ] ; 2003-03.
Descripteurs français
- Wicri :
- topic : Médiateur.
English descriptors
- KwdEn :
- Antisense, Astrocyte, Astrocyte cultures, Astrocytic, Astroglial, Benveniste, Boehringer ingelheim, Brain parenchyma, Ccr2, Ccr3, Ccr5, Ccr8, Cdna, Cell surface molecule expression, Chemokine, Chemokine expression, Chemokine expression patterns, Chemokine production, Chemokine receptor expression, Chemokine receptors, Chemokines, Cheret, Choe, Clone, Coreceptor, Coreceptors, Cxcr4, Cxcr4 expression, Cytokine, Cytokine treatment, Cytometry, Dementia, Different antibodies, Dorf, Encephalitis, Functional expression, Gapdh, Glia, Glial, Gpr1, Human astrocytes, Human virus type, Immunol, Klein, Lavi, Lesser extent, Major coreceptors, Mediator, Microglial, Monoclonal antibodies, Mrna, Mrna expression, Mrna levels, Multiple sclerosis, Neuroimmunol, Neuron, Neurovirol, Positive control, Primer, Protein levels, Ransohoff, Receptor, Room temperature, Sabri, Simian, Simian adult astrocytes, Simian astrocytes, Synergistic effect, Villinger, Wang, Westmoreland.
- Teeft :
- Antisense, Astrocyte, Astrocyte cultures, Astrocytic, Astroglial, Benveniste, Boehringer ingelheim, Brain parenchyma, Ccr2, Ccr3, Ccr5, Ccr8, Cdna, Cell surface molecule expression, Chemokine, Chemokine expression, Chemokine expression patterns, Chemokine production, Chemokine receptor expression, Chemokine receptors, Chemokines, Cheret, Choe, Clone, Coreceptor, Coreceptors, Cxcr4, Cxcr4 expression, Cytokine, Cytokine treatment, Cytometry, Dementia, Different antibodies, Dorf, Encephalitis, Functional expression, Gapdh, Glia, Glial, Gpr1, Human astrocytes, Human virus type, Immunol, Klein, Lavi, Lesser extent, Major coreceptors, Mediator, Microglial, Monoclonal antibodies, Mrna, Mrna expression, Mrna levels, Multiple sclerosis, Neuroimmunol, Neuron, Neurovirol, Positive control, Primer, Protein levels, Ransohoff, Receptor, Room temperature, Sabri, Simian, Simian adult astrocytes, Simian astrocytes, Synergistic effect, Villinger, Wang, Westmoreland.
Abstract
Chemokines are key mediators of the selective migration of leukocytes that occurs in neurodegenerative diseases and related inflammatory processes. Astrocytes, the most abundant cell type in the CNS, have an active role in brain inflammation. To ascertain the role of astrocytes during neuropathological processes, we have investigated in two models of primary cells (human fetal and simian adult astrocytes) the repertoire of chemokines and their receptors expressed in response to inflammatory stimuli. We demonstrated that, in the absence of any stimulation, human fetal and simian adult astrocytes express mRNA for receptors APJ, BOB/GPR15, Bonzo/CXCR6, CCR2, CCR3, CCR5, CCR8, ChemR23, CXCR3/GPR9, CXCR4, GPR1, and V28/CX3CR1. Moreover, TNFα and IL‐1β significantly increase BOB/GPR15, CCR2, and V28/CX3CR1 mRNA levels in both models. Furthermore, TNFα and IFNγ act synergistically to induce expression of the major coreceptors for HIV infection, CXCR4 and CCR5, at both the mRNA and protein levels in human and simian astrocytes, whereas CCR3 expression was not affected by cytokine treatment. Finally, TNFα/IFNγ was the most significant cytokine combination in leading to a pronounced upregulation in a comparable, time‐dependent manner of the production of chemokines IP‐10/CXCL10, RANTES/CCL5, MIG/CXCL9, MCP‐1/CCL2, and IL‐8/CXCL8. In summary, these data suggest that astrocytes serve as an important source of chemokines under the dependence of a complex cytokine regulation, and TNFα and IFNγ are important modulators of chemokines and chemokine receptor expression in human as well as simian astrocytes. Finally, with the conditions we used, there was no difference between species or age of tissue. GLIA 41:354–370, 2003. © 2003 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/glia.10181
Affiliations:
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Guillemin</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Immunology, St. Vincent's Hospital, University of New South Wales, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Boussin, Francois D" sort="Boussin, Francois D" uniqKey="Boussin F" first="François D." last="Boussin">François D. Boussin</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Radiopathologie, Commissariat à l'Energie Atomique, Fontenay‐aux‐Roses Cedex</wicri:regionArea><wicri:noRegion>Fontenay‐aux‐Roses Cedex</wicri:noRegion><wicri:noRegion>Fontenay‐aux‐Roses Cedex</wicri:noRegion></affiliation></author><author><name sortKey="Mognetti, Barbara" sort="Mognetti, Barbara" uniqKey="Mognetti B" first="Barbara" last="Mognetti">Barbara Mognetti</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Radiopathologie, Commissariat à l'Energie Atomique, Fontenay‐aux‐Roses Cedex</wicri:regionArea><wicri:noRegion>Fontenay‐aux‐Roses Cedex</wicri:noRegion><wicri:noRegion>Fontenay‐aux‐Roses Cedex</wicri:noRegion></affiliation></author><author><name sortKey="Gigout, Laure I" sort="Gigout, Laure I" uniqKey="Gigout L" first="Laure I." last="Gigout">Laure I. Gigout</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurovirologie, Commissariat à l'Energie Atomique, Fontenay‐aux‐Roses Cedex</wicri:regionArea><wicri:noRegion>Fontenay‐aux‐Roses Cedex</wicri:noRegion><wicri:noRegion>Fontenay‐aux‐Roses Cedex</wicri:noRegion></affiliation></author><author><name sortKey="Cheret, Arnaud" sort="Cheret, Arnaud" uniqKey="Cheret A" first="Arnaud" last="Chéret">Arnaud Chéret</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurovirologie, Commissariat à l'Energie Atomique, Fontenay‐aux‐Roses Cedex</wicri:regionArea><wicri:noRegion>Fontenay‐aux‐Roses Cedex</wicri:noRegion><wicri:noRegion>Fontenay‐aux‐Roses Cedex</wicri:noRegion></affiliation></author><author><name sortKey="Vaslin, Bruno" sort="Vaslin, Bruno" uniqKey="Vaslin B" first="Bruno" last="Vaslin">Bruno Vaslin</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurovirologie, Commissariat à l'Energie Atomique, Fontenay‐aux‐Roses Cedex</wicri:regionArea><wicri:noRegion>Fontenay‐aux‐Roses Cedex</wicri:noRegion><wicri:noRegion>Fontenay‐aux‐Roses Cedex</wicri:noRegion></affiliation></author><author><name sortKey="Le Grand, Roger" sort="Le Grand, Roger" uniqKey="Le Grand R" first="Roger" last="Le Grand">Roger Le Grand</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurovirologie, Commissariat à l'Energie Atomique, Fontenay‐aux‐Roses Cedex</wicri:regionArea><wicri:noRegion>Fontenay‐aux‐Roses Cedex</wicri:noRegion><wicri:noRegion>Fontenay‐aux‐Roses Cedex</wicri:noRegion></affiliation></author><author><name sortKey="Brew, Bruce J" sort="Brew, Bruce J" uniqKey="Brew B" first="Bruce J." last="Brew">Bruce J. Brew</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Immunology, St. Vincent's Hospital, University of New South Wales, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Departments of Neurology and HIV Medicine, St. Vincent's Hospital, University of New South Wales, Sydney New South Wales</wicri:regionArea><wicri:noRegion>Sydney New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Dormont, Dominique" sort="Dormont, Dominique" uniqKey="Dormont D" first="Dominique" last="Dormont">Dominique Dormont</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurovirologie, Commissariat à l'Energie Atomique, Fontenay‐aux‐Roses Cedex</wicri:regionArea><wicri:noRegion>Fontenay‐aux‐Roses Cedex</wicri:noRegion><wicri:noRegion>Fontenay‐aux‐Roses Cedex</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Glia</title><title level="j" type="alt">GLIA</title><idno type="ISSN">0894-1491</idno><idno type="eISSN">1098-1136</idno><imprint><biblScope unit="vol">41</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="354">354</biblScope><biblScope unit="page" to="370">370</biblScope><biblScope unit="page-count">17</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2003-03">2003-03</date></imprint><idno type="ISSN">0894-1491</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0894-1491</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antisense</term><term>Astrocyte</term><term>Astrocyte cultures</term><term>Astrocytic</term><term>Astroglial</term><term>Benveniste</term><term>Boehringer ingelheim</term><term>Brain parenchyma</term><term>Ccr2</term><term>Ccr3</term><term>Ccr5</term><term>Ccr8</term><term>Cdna</term><term>Cell surface molecule expression</term><term>Chemokine</term><term>Chemokine expression</term><term>Chemokine expression patterns</term><term>Chemokine production</term><term>Chemokine receptor expression</term><term>Chemokine receptors</term><term>Chemokines</term><term>Cheret</term><term>Choe</term><term>Clone</term><term>Coreceptor</term><term>Coreceptors</term><term>Cxcr4</term><term>Cxcr4 expression</term><term>Cytokine</term><term>Cytokine treatment</term><term>Cytometry</term><term>Dementia</term><term>Different antibodies</term><term>Dorf</term><term>Encephalitis</term><term>Functional expression</term><term>Gapdh</term><term>Glia</term><term>Glial</term><term>Gpr1</term><term>Human astrocytes</term><term>Human virus type</term><term>Immunol</term><term>Klein</term><term>Lavi</term><term>Lesser extent</term><term>Major coreceptors</term><term>Mediator</term><term>Microglial</term><term>Monoclonal antibodies</term><term>Mrna</term><term>Mrna expression</term><term>Mrna levels</term><term>Multiple sclerosis</term><term>Neuroimmunol</term><term>Neuron</term><term>Neurovirol</term><term>Positive control</term><term>Primer</term><term>Protein levels</term><term>Ransohoff</term><term>Receptor</term><term>Room temperature</term><term>Sabri</term><term>Simian</term><term>Simian adult astrocytes</term><term>Simian astrocytes</term><term>Synergistic effect</term><term>Villinger</term><term>Wang</term><term>Westmoreland</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Antisense</term><term>Astrocyte</term><term>Astrocyte cultures</term><term>Astrocytic</term><term>Astroglial</term><term>Benveniste</term><term>Boehringer ingelheim</term><term>Brain parenchyma</term><term>Ccr2</term><term>Ccr3</term><term>Ccr5</term><term>Ccr8</term><term>Cdna</term><term>Cell surface molecule expression</term><term>Chemokine</term><term>Chemokine expression</term><term>Chemokine expression patterns</term><term>Chemokine production</term><term>Chemokine receptor expression</term><term>Chemokine receptors</term><term>Chemokines</term><term>Cheret</term><term>Choe</term><term>Clone</term><term>Coreceptor</term><term>Coreceptors</term><term>Cxcr4</term><term>Cxcr4 expression</term><term>Cytokine</term><term>Cytokine treatment</term><term>Cytometry</term><term>Dementia</term><term>Different antibodies</term><term>Dorf</term><term>Encephalitis</term><term>Functional expression</term><term>Gapdh</term><term>Glia</term><term>Glial</term><term>Gpr1</term><term>Human astrocytes</term><term>Human virus type</term><term>Immunol</term><term>Klein</term><term>Lavi</term><term>Lesser extent</term><term>Major coreceptors</term><term>Mediator</term><term>Microglial</term><term>Monoclonal antibodies</term><term>Mrna</term><term>Mrna expression</term><term>Mrna levels</term><term>Multiple sclerosis</term><term>Neuroimmunol</term><term>Neuron</term><term>Neurovirol</term><term>Positive control</term><term>Primer</term><term>Protein levels</term><term>Ransohoff</term><term>Receptor</term><term>Room temperature</term><term>Sabri</term><term>Simian</term><term>Simian adult astrocytes</term><term>Simian astrocytes</term><term>Synergistic effect</term><term>Villinger</term><term>Wang</term><term>Westmoreland</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Médiateur</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chemokines are key mediators of the selective migration of leukocytes that occurs in neurodegenerative diseases and related inflammatory processes. Astrocytes, the most abundant cell type in the CNS, have an active role in brain inflammation. To ascertain the role of astrocytes during neuropathological processes, we have investigated in two models of primary cells (human fetal and simian adult astrocytes) the repertoire of chemokines and their receptors expressed in response to inflammatory stimuli. We demonstrated that, in the absence of any stimulation, human fetal and simian adult astrocytes express mRNA for receptors APJ, BOB/GPR15, Bonzo/CXCR6, CCR2, CCR3, CCR5, CCR8, ChemR23, CXCR3/GPR9, CXCR4, GPR1, and V28/CX3CR1. Moreover, TNFα and IL‐1β significantly increase BOB/GPR15, CCR2, and V28/CX3CR1 mRNA levels in both models. Furthermore, TNFα and IFNγ act synergistically to induce expression of the major coreceptors for HIV infection, CXCR4 and CCR5, at both the mRNA and protein levels in human and simian astrocytes, whereas CCR3 expression was not affected by cytokine treatment. Finally, TNFα/IFNγ was the most significant cytokine combination in leading to a pronounced upregulation in a comparable, time‐dependent manner of the production of chemokines IP‐10/CXCL10, RANTES/CCL5, MIG/CXCL9, MCP‐1/CCL2, and IL‐8/CXCL8. In summary, these data suggest that astrocytes serve as an important source of chemokines under the dependence of a complex cytokine regulation, and TNFα and IFNγ are important modulators of chemokines and chemokine receptor expression in human as well as simian astrocytes. Finally, with the conditions we used, there was no difference between species or age of tissue. GLIA 41:354–370, 2003. © 2003 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Croitoru Amoury, Juliana" sort="Croitoru Amoury, Juliana" uniqKey="Croitoru Amoury J" first="Juliana" last="Croitoru-Lamoury">Juliana Croitoru-Lamoury</name></noRegion><name sortKey="Boussin, Francois D" sort="Boussin, Francois D" uniqKey="Boussin F" first="François D." last="Boussin">François D. Boussin</name><name sortKey="Cheret, Arnaud" sort="Cheret, Arnaud" uniqKey="Cheret A" first="Arnaud" last="Chéret">Arnaud Chéret</name><name sortKey="Dormont, Dominique" sort="Dormont, Dominique" uniqKey="Dormont D" first="Dominique" last="Dormont">Dominique Dormont</name><name sortKey="Gigout, Laure I" sort="Gigout, Laure I" uniqKey="Gigout L" first="Laure I." last="Gigout">Laure I. Gigout</name><name sortKey="Le Grand, Roger" sort="Le Grand, Roger" uniqKey="Le Grand R" first="Roger" last="Le Grand">Roger Le Grand</name><name sortKey="Mognetti, Barbara" sort="Mognetti, Barbara" uniqKey="Mognetti B" first="Barbara" last="Mognetti">Barbara Mognetti</name><name sortKey="Vaslin, Bruno" sort="Vaslin, Bruno" uniqKey="Vaslin B" first="Bruno" last="Vaslin">Bruno Vaslin</name></country><country name="Australie"><noRegion><name sortKey="Croitoru Amoury, Juliana" sort="Croitoru Amoury, Juliana" uniqKey="Croitoru Amoury J" first="Juliana" last="Croitoru-Lamoury">Juliana Croitoru-Lamoury</name></noRegion><name sortKey="Brew, Bruce J" sort="Brew, Bruce J" uniqKey="Brew B" first="Bruce J." last="Brew">Bruce J. Brew</name><name sortKey="Brew, Bruce J" sort="Brew, Bruce J" uniqKey="Brew B" first="Bruce J." last="Brew">Bruce J. Brew</name><name sortKey="Croitoru Amoury, Juliana" sort="Croitoru Amoury, Juliana" uniqKey="Croitoru Amoury J" first="Juliana" last="Croitoru-Lamoury">Juliana Croitoru-Lamoury</name><name sortKey="Croitoru Amoury, Juliana" sort="Croitoru Amoury, Juliana" uniqKey="Croitoru Amoury J" first="Juliana" last="Croitoru-Lamoury">Juliana Croitoru-Lamoury</name><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J." last="Guillemin">Gilles J. Guillemin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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